This Billionaire Investor in OpenAI and Instacart Says AI Will Be Able to Do 80% of Jobs in 5 Years. Here’s What He Sees As ‘the Most Valuable Skill In the AI Era.’

Venture capitalist Vinod Khosla tells Entrepreneur that AI will dramatically reshape labor and investment opportunities, predicting AI could perform 80% of jobs by 2030. He highlights investments including a $27 million Series A for Nas.com and prior backing of OpenAI and DoorDash, arguing AI tools will democratize coding, marketing and design and spawn millions of new entrepreneurs. Khosla urges founders with high learning rates and contrarian, non-incremental visions, and flags healthcare and education as large sectors still ripe for bold AI-driven disruption. Market impact: accelerated startup formation, concentrated opportunities for incumbent obsolescence on cost/quality/speed, and sector-level reallocations of capital toward AI-native business models.