Amazon, UnitedHealth rise premarket; 3M declines

U.S. stock futures drifted higher premarket on April 21, 2026, as investors weighed Middle East peace-talk uncertainty and the upcoming Fed chair confirmation hearing. Dow futures jumped about 274 points (0.6%), S&P 500 futures rose ~0.3% and Nasdaq 100 futures climbed ~0.4%. Major premarket movers included Amazon (AMZN.OQ), which gained over 2% after announcing up to $25 billion in investment in AI startup Anthropic (boosting some suppliers), UnitedHealth (UNH.N), which rose after an upbeat annual outlook, and 3M, which fell after disappointing organic growth. The tone was mixed across sectors with tech and defense names showing varied responses to corporate updates.